CHEM564 Lecture Notes - Lecture 19: Cardiovascular Disease, Immune Thrombocytopenic Purpura, Thrombosis
2 May 2017
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Document Summary
Itp patients need less immunosuppressive therapy and it is a good alternative for other therapies such as. For acute bleeding, anti-d antibodies and platelet transfusions are necessary treatment. Although splenectomy is an effective treatment for who are incompatible to other methods, physicians try to postpone this surgery because of its inherent risks in the procedure. 1. Pharmacodynamic/pharmacokinetic results has proved that although this dug is active in some animals such as dogs, mice, rabbits, rats, and monkeys, nonhuman primates (nhp) show less responses compared to humans. According to the nhp data, 10 g/kg dose was a no-effect dose. Surprisingly, in phase 1, when the first volunteer received this dose, his platelet counts raised sixfold above baseline. Results of this trial reveal the relationship between dose and response. Dose of 1 and 3 g/kg can double the platelet counts in healthy humans.
