BMS 860 Lecture Notes - Lecture 22: Microrna, Bioavailability, Blood Vessel

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Translational research: the process of applying new knowledge, mechanisms and techniques generated by advances in basic science research into new approaches for prevention, diagnosis, and treatment of disease. Model for translational research: basic research includes drug development and study of disease mechanisms, patient oriented research is research that is used to affect the clinical practice, population based research- epidemiology, public health policies, cost effective options. Drug discovery phase: basic research and drug discovery can take 2-10 years, choose a disease, choose a drug target- protein, pathway, choose a (cid:862)(cid:271)ioassa(cid:455)(cid:863) to (cid:448)alidate the target/drug, find a lead compound, preclinical testing of lead compounds. High throughput screening (hts: process by which large number of compounds are rapidly tested for their ability to modify the properties of a selected biological target. It involves testing a large number of compounds versus a large number of targets: the test should produce easily measurable effect, cell proliferation, apoptosis, cell morphology (microscopy)

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