MCDB 423 Lecture Notes - Lecture 21: Nmda Receptor, Wild Type, Amacrine Cell

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We talked about development of the eye specific connection in the lgn and cortex. The paper we talked about is talking about the retinotopic map that is formed in the superior colliculus (sc) Rgc makes connections to both lgn and sc. Sc is i(cid:373)porta(cid:374)t for (cid:448)isio(cid:374); (cid:272)a(cid:374) see it"s fu(cid:374)(cid:272)tio(cid:374)al e(cid:448)e(cid:374)t (cid:373)ore i(cid:374) frogs tha(cid:374) i(cid:374) (cid:373)a(cid:373)(cid:373)als (i(cid:374) mammals, lgn and visual cortex play a bigger role in vision) Axons from rgc target to specific layers to the lgn and lgn targets themselves to specific regions in the cortex. One of the axons is from the ipsi and the other is from the contralateral. Early in development, these axons are forming branches from multiple areas of the lgn but make more connections in one layer and prune ones in other layers. You can see that the axons at p1 are making contacting a large region of the sc. Ultimately this leads to making more specific connection to the posy-synaptic cells.

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