MBIO 1010 Lecture Notes - Lecture 25: Kanamycin A, Lactam, Lactone

• School: University of Manitoba
• Department: Microbiology
• Course: MBIO 1010
• Professor: Christopher Rathgeber

Document Summary

Cell wall synthesis inhibitors, e. g. penicillins and cephalosporins . Comprise of over 50% of antibiotics used around the world . Some synthetic forms active against gram- negative bacteria. Bacterialstatic keeps it constant = rely on a functioning immune system. Bacterialccidal it destroys the bacterium to it(cid:859)s entirety. Urinary track infections usually gram neg. (cid:1006)7. (cid:1005)(cid:1007) -lactam antibiotics: penicillins and cephalosporins. Cephalosporins : fungus, cephalosporium sp, structurally different from penicillins. Microbiology 1010 lecture notes (cid:1006)7. (cid:1005)(cid:1007) -lactam antibiotics: penicillins and cephalosporins (cid:894)continued (cid:895) Cephalosporins : similar mode of action to penicillins, broader spectrum than penicillins, resistant to -lactamases, commonly used to treat gonorrhea. Where the bacteria shows resistance to the b- la(cid:272)ta(cid:373) . Cephalospori(cid:374)"s are resistant to the resistance of the bacteria\ Target 30s subunit of the ribosome: useful against gram-negative bacteria. Macrolides : lactone rings bonded to sugars, e. g. erythromycin (streptomyces erythreus, broad spectrum. Partial inhibition of protein synthesis preferential translation of some proteins .