BIO152H5 Lecture Notes - Lecture 12: Cellular Respiration, Pyruvic Acid

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13 May 2017
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First: the 2 pyruvate molecules formed in glycolysis are transported through the mitochondrial membranes into the matrix. Next: a multi-enzyme complex catalyzes 3 reactions: a carboxyl group is removed by a decarboxylase enzyme producing co2. (which diffuses out of the cell as waste), remaining 2-carbon portion is oxidized by nad+ to become acetic acid. Nad+ gains 2 hydrogen atoms (from organic molecules of food) and becomes. Nadh + h+ (nadh will be used later and h+ stays dissolved in the matrix: a sulfur-containing compound called coenzyme a (coa) is attached to the oxidized 2-carbon compound (acetic acid) to form acetyl-coa. The goal: to prepare glucose derivatives for further oxidation in the krebs cycle. 2 pyruvate + 2 nad+ + 2coa 2 acetyl-coa + 2nadh + h+ + 2co2. Proteins and lipids are also converted to acetyl-coa. If the body needs energy, acetyl-coa goes into the.

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