BIOL 1090 Lecture Notes - Lecture 1: Histone H3, Nucleic Acid Double Helix, Nucleosome

• School: University of Guelph
• Department: Biology
• Course: BIOL 1090
• Professor: Andrew Bendall

Document Summary

Function of genetic material: replication > genotypic function. Final phenotype is both due environment and genetics factors: mutation evolutionary function, variation within any population. Frequency of different version of different genes how natural selection works: dna, acid, polymer, made of covalent bonds, nucleotide made of phosphate group, 5 carbon sugar (2-deoxyribose) and one of four cyclic nitrogenous bases. Joined by phosphodiester bonds links each nucleotide in a chain: pyrimidines t and c (single bonded, purines a and g (double bonded, dna is a polar molecule. Longer pieces of dna are more stable: variation within the width of the groove. 2 different grooves minor and major groove: a- dna has more torque, more compact, z- dna left twist, we have 2 meters worth of dna, diameter of nucleus is 0. 006 mm. 146 base pairs wrap around nucleosome: nucleosome is composed of 8 histones (4 differents kinds linker dna varies from 8 to 114 nucleotide pairs.