IMM250H1 Lecture Notes - Lecture 8: Micelle, Influenza A Virus Subtype H5N1, Endosome
8 Apr 2013
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Document Summary
Negative strand: carries the template of what it replicates to infiltrate cells. Acidic composition of the endosome of the infiltrated cells causes transformational change to cause virus envelope to attach to endosome and release viral components . Use fertilized chicken eggs: strip it of its rna, but not the proteins, dominant protein is hemagluttinin. 1918: started as a normal flu, disappeared, came back stronger. H1n1: adjuvant: use less vaccine but get same response. Mix that with a hemagluttinin and neuraminidase mixture and they embed into the micelles. Looks like a virus, multiple copies that aggregate.
