IMM250H1 Lecture Notes - Lecture 4: Histamine, Opsonin, Anticoagulant
Document Summary
Imm250 lecture 4 -innate immunity: cellular and humoral mediators of defense. Nod-like receptors - cytosolic sensors of bacteria and danger: nlr proteins : detects mamps and damps, nlr have two families, nod subfamily detects peptidoglycan which some into the cytosol ; nod 1 and. Nod 2: nlrp subfamily in the cytosol; detects damps high levels of ros, and k+ efflux. Nlrps detect danger and form the inflammasome : nlrp3 is the sensor, and asc is the adapter. There is a conformational change and then it binds to the adapter. Asc binds to nlrp3 through the pyrin pyrin domain: the domains in the end of the adapter and nlrp3 is important. it helps to bind the proteins and form a complex. Similar to pyrin domain of tlr: which is similar to domain of tlr it has a transmembrane domain, and a cytoplasmic domain, nod domain nucloetide binding domain.
