NURS 2050 Lecture Notes - Gingival Enlargement, Anticonvulsant, Valproate
11 Apr 2013
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Moa: blocks na channels, prolongs the inactivated state, blocks the rapid firing neurons. ** starts out as first order (drug elimination is proportional to amount of drug left in body), but then ends up zero order (not proportional) Is an enzyme inducer (speeds up effects of other drugs) Is metabolized by cyp450, so other drugs can increase/decrease effects. Side effects: gingival hyperplasia, cns: nystagmus (eye flickers), sedation, diplopia, ataxia. ** is an autoinducer (can speed up its own metabolism) T first dose: 40 hrs, second dose: 15-20 hrs. Moa: gaba (inhibitory), allows influx of cl, which decreases ap"s. Side effects: cns: dizzy, drowsy, skin rx: steven johnson, hematologic: leuko, thrombopenia, anemia, weight gain, edema, hyponatremia, gi, hepatotoxicity, pancreatitis, minimal cns, cns depression, amnesic, resp depression, teratogeneisis, paradoxial effects. Consider all of them for hepatotoxicty, effects on fetus, withdrawl reactions, and narrow therapeutic range.
