NURS 2050 Lecture Notes - Cytochrome P450, Levothyroxine, Iodine
11 Apr 2013
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Shorter t1/2 and duration of action given bid. Adverse effect profile more cv effects. Bottom line no more effective than levothyroxine. More t4 than t3 released from gland (5:1) (majority of t4 released is converted in the periphery to. Half life: 1 week (takes 4-5 weeks to get to steady state) miss one pill = not a big deal, its a once a day drug. Highly protein bound and hepatically metabolized (some cyp 450 interactions) Drug interactions: absorption: cholestyramine, antacids, iron, calcium supplements, warfari: the degradation of vit k dependent clotting factors ( inr, lithium: thyroid hormone release, amiodarone: contains iodine & can cause hypo/hyperthyroidism, catecholamines: cardiac responsiveness. Used when: patients unable to take p. o. for extended periods, or emergency situations (e. g. myxedema coma) Exhaustion of inflammatory and immune breaking down proteins, releasing lipids, responses increasing glucose. Excessive loss of body proteins and break down of tissues. Prevent release of chemical mediators that trigger inflammatory response.
