PSYC12H3 Chapter Notes -Autocrine Signalling, Sex Organ, E2F
Document Summary
Using juvenile roosters, berthold wanted to determine the role of testis in male sexual development. Castrated roosters displayed normal social behaviour and did not develop secondary sex characteristics. Testis produces some signalling molecules which dictate male sexual development and the signal may be carried to closer sites via the blood. Castrated roosters displayed abnormal social behaviour and did not develop primary sex characteristics. Transplanted testis did not re-establish a connection to the circulatory system. Testis produces some signalling molecules which dictate male sexual development and the signal may be carried to distant sites via the blood. When rb protein interacts with e2f, the synthesis of s-phase proteins is repressed. In normal cells, s-phase is initiated when cdk phosphorylates rb. In a cell infected with hpv, the promoter of the s-phase genes is constitutively turned off. Mutations must be present in both copies of the rb gene to result in a loss of growth control.
