LMP299Y1 Lecture Notes - Lecture 8: Congenital Hypothyroidism, Thyroid, Thyrotropin Receptor

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It can be associated with both hyperthyroidism and hypothyroidism. The patient may also have normal thyroid function. Thyroid gland secreted mostly t4 and some t3. The peripheral tissues (e. g. the liver and kidney) deiodinate (convert) t4 to produce 2/3 of the circulating t3. Thyroid hormones bind to receptors and trigger the hormonal effects. T3 is more biologically active than t4, but at a lower concentration in plasma (2 nmol/l for t3 vs 100 nmol/l for t4) Reverse t3 (rt3) is an inactive form metabolized from t4. Local thyroid status can be modulated by the relative production of t3 and rt3. Thyroid hormones are essential for the normal maturation and metabolism of all the tissues in the body. Reverse t3 and is the inactive form this is how the peripheral issue can fine tune the levels of t3 in the body.

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