Biology 1002B Lecture Notes - Superoxide, Oxidative Stress, Nadh Dehydrogenase
15 Apr 2013
School
Department
Course
Professor
Document Summary
Progressive impairment of function with an increasing probability of death: factors are environmental, metabolic, genetics, life expectancy has increased over the years 1800s 28yrs to 2000 73 yrs. Reactive oxygen species (ros: ros implicated in aging, paradox of aerobic life, o2 -> superoxide -> hydrogen peroxide -> hydroxyl radical -> h2o, catalase superoxide mutase. Mitochondria: major source of ros: cytochrome oxidase donates electrons to oxygen. Partially reduced forms, like ros (can be created by donating: cytochrome oxidase donates 4 electrons at a time, Some parkinson"s disease linked to complex 1, the nadh dehydrogenase. Als amyotrophic lateral sclerosis some are linked to sod1, doesn"t make enough or not efficient enough. Cytochrome complex mutation: caenorhabditis elegans (c. elegans) worm, mutation cytochrome complex (less efficient, the more oxygen in the environment, the mutants will not survive, they don"t live as long as non-mutants. Japanese centenarians (genetics?: complex 1 (nadh dehydrogenase) and complex 5 (atp synthase) and mitochondrial ribosomes.
