MIMM 465 Lecture 7: Lecture 7.docx
Document Summary
Influenza virus a human, pig, bird, horse. Thogotovirus (thogoto virus, choir virus) mosquito, mammals. Influenza a and b causes the most human pandemics annually. Pleomorphic morphology they have different morphology, such as spherical or filament morphology. Ha and na as neutralization antigens + m2 = 3 surface proteins. Ha binds to the host cell receptor. Na cleave the receptor so the particle can leave. Pa, pb1 and pb2 proteins = together form a complex, transcription machinery. Np protein rna binding protein (will hold and protect the viral genome) Influenza c virus carries 7 rna segments, while influenza b virus has 8 segments. Ha and na major ags that trigger immune system to produce abs. H1n1: spanish flu in 1918, swine flu in 2009. You can recover the old influenza virus from the dead body. Earliest h1n1, spanish flu in 1918. H1n1 and h3n2 major components of seasonal flu. Antigenic drift of ha protein: a result of the viral error-prone polymerase.