PHA3112- Midterm Exam Guide - Comprehensive Notes for the exam ( 22 pages long!)

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Parkinsons: we convert to da in the brain. One of us blocks the destruction of the other, and we are a first line drug. I directly activate da receptors, and i"m used as a first line drug supplement or to supplement levodopa. I inhibit the breakdown of levodopa by comt, i"m safer than levodopa. I inhibit the breakdown of dopamine by mao-8, i"m used for newly diagnosed patients and for. I promote the release of da from remaining da neurons: i may also block da reuptake, and may help reduce levodopa induced dyskinesia. I block muscarinic ach receptors in the striatum, and i block pns ach receptors. Some include dry mouth, constipation, urinary retention, tachycardia, photophobia and blurred vision. I have a safety alert to not use in elderly. I help treat the symptoms of ad, and i block neuronal receptors for nmda. I am a cholinesterase inhibitor, and i produce only a modest improvement in cognitive function.