Biology 1002B Study Guide - Final Guide: Tumor Suppressor Gene, Natty, Synonymous Substitution
20 Apr 2013
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Four most common types of cancer in canada: breast, prostate, lung, colorectal, leading cause of premature death in canada, 25% of canadians can expect to die of cancer. Likely factors contributing to cancer incidence in canada: men are at higher risk for cancer than women, rates among youth are rising. Role of cyclin/cdk complexes in cell cycle regulation. G1s checkpoint prevents cell from replicating it s dna if it s damaged until everything is repaired which is monitored by cdk (cyclin-dependent kinase) Cyclin production cycles are with cell cycle produced early on and binds & activates. Cdk complex then phosphorylates whole bunch of targets downstream, releasing the. Example of post-translational regulation of protein function. Inappropriate expression of mirna can promote cycling: oncomirs. Biology 1002 natty liu: micro rnas turn out to be very integral in cell division / regulation, heatmap shows mirna overexpressed (red) / underexpressed (blue)
