Biology 1002B Lecture Notes - Superoxide Dismutase, Cytochrome C Oxidase, Hyperoxia
21 Apr 2013
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Lecture 23: oxygen and aging: what are the major forms of reaction oxygen and how are they formed (see figure 6. 25). The intermediates are very toxic and reactive: role of cytochrome oxidase in production of ros. Oxygen accepts electrons at reduced q to make superoxide: oxygen in matrix of mitochondria compete with cytochrome complex. So much oxygen, bound to get electron leak from q. Sod converts superoxide to hydrogen peroxide and destroys mitochondria: how defects in mitochondrial function might lead to disease. Produce less energy since mitochondria isn"t as efficient. Any defects would increase electron leak and produce ros: human diseases associated with mitochondrial dysfunction. Als (amyotrophic lateral sclerosis) mutation to sod 1 enzyme (not as efficient: cannot get rid of ros. Some parkinson"s diseases nadh dehydrogenase defect (complex i electron leak: how defects in cytochrome complex lead to increased oxygen toxicity in c. elegans. Mutation causes cytochrome complex to work as not efficiently as its wildtype.
