PS282 Chapter Notes - Chapter 18: Methadone Maintenance, Opioid Antagonist, Opioid Use Disorder
Document Summary
Detoxification: initial and immediate goal during which medications are administered to alleviate unpleasant withdrawal symptoms that may appear following abrupt cessation of drug use. Agonist or substitution therapy: cross tolerance to the abused drug. Antagonist therapy: used to produce extinction by preventing the user from experiencing the reinforcing effects of the abused drug. Aversion therapy: used to produce an aversive reaction following ingestion of the abused drug: disulfiram: (antabuse) for the treatment of alcohol dependence is an example of aversion therapy. Inhibits aldehyde dehydrogenase, a major enzyme involved in alcohol metabolism which with alcohol: alcohol can produce unpleasant symptoms: vomiting, headache, breathing difficulties. Canada for treatment of alcohol abuse and dependence at 72. Acamprosate (campral: latest medication to get approval for the treatment of. Not approved by health canada: problems with frequent use, 1/11 users will become dependent, withdrawal symptoms: irritability, anxiety, sleep, treatment drug: dronabinol.
