BIO130H1 Study Guide - Tight Junction, Desmoglein, Connexin
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BIO130H1 Full Course Notes
Verified Note
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Document Summary
Gap junctions x e l p m o. Made of 2 transmembrane proteins: claudin and occludin, needs matching sequence in both. Several sealing strands wrap around cell to from a seal. Dependent on formation of adherens juntions actin filament. Cadherins: adhesion protein, transmembrane, bundles extracellular domains interact with neighboring. > cytoskeletal filaments and cytosolic proteins intermediate filaments (most structural strength) Can be heterotypic or homotypic, 6 connexins=1 connexon, Gated, closed by inc of [ca]; prevent ca to leak in and metabolite leak out ([ca] should be low in cytosol) Prevents fibroblasts in the underlying connective tissue from interacting with epithelial cells. Ecm: laminin, type 4 collagen, nidogen, fibrillar collagen, fibronectin, perlecan, hyaluronan, decorin, aggrecan. Made with trimer of laminin, binds to integrins and other components of ecm.
