Biochemistry 3386B Lecture Notes - Maple Syrup Urine Disease, Diabetes Insipidus, Hyperemesis Gravidarum

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Unique material for producing many answers without stress to the patient. Urine produced by an ultrafiltration process of blood flowing through the glomerulus in the glomerular nephrons. Ultrafiltrate contains: water, waste products, small molecules that passed through the membrane pores. Ultrafiltrate is then also passed through: proximal tubule, loop of henle, distal tubule, collecting ducts, bladder. Re-absorption of: water, glucose, salts (electrolytes) There are other products that are secreted into the filtrate or re-absorbed back into the plasma during passage through the loh. This process is aided by osmotic gradients and hormonal regulation (ie. adh and water reabsorption) Random: refers to a single urine sample (ie. the preferred 1st morning voiding) store at room temperature (as long as the processing is done in 2 hours) Timed: several specimens collected and pooled together over a time interval (24 or 8 hours are the most common (store at 4 degrees)

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