PHGY 210 Lecture Notes - External Intercostal Muscles, Transpulmonary Pressure, Pulmonary Circulation
6 May 2013
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Dr. white: orphan receptors refer to receptors that, upon discovery, did not have any known physiological ligands. 1: fxr is actually a receptor for bile acids. In bile acids, we have lost a sidechain of cholesterol and replaced it with a water- soluble carboxylic acid. They represent solubilized excretable forms of cholesterol. In this way, gene expression can be monitored tens of thousands of genes at a time. ** note: will not be tested on how microarrays work on the exam** New insights into vitamin d physiology. 1,25- dihydroxyvitamin d3 biosynthesis: provitamin d3 (7- dihydocholesterol) gets converted to. 1,25 dihydroxyvitamin d3: this is the horomonally active form, the 1- hydroxylation reaction (kidney) is stimulated by parathyroid hormone (pth) In montreal, we have roughly 6 months a year: many of major population centers in europe are more northernly. Scandinavian countries supplement with cod- liver oil to combat vitamin d3 deficiency.
