PCL102H1 Lecture Notes - Mianserin, Inositol, Bupropion
Document Summary
Therapy for mood disorders: chapter 25 in dept text, Antidepressant drugs: work in about 70% of people and takes about a month. Tms: prolonged temporal-lobe epilepsy schizophrenia and tonic-clonic seizures leading to forced normalization was the motivation for this. Treatment of choice for drug- resistant depressives: transcranial magnetic stimulation. Found it blocked h1 receptor in brain and made you sleepy. Playing with the anti-histamines enabled the advent of chlorpromazine (first antipsychotic). Depression: antidepressants: tricyclic antidepressants (tcas) block 5ht and ne reuptake. Work on a lot of people with a 3-4 week delay: monoamine oxidase inhibitors (maois) Came out in the late 1950s (a tiny bit before the tricyclics) Probably as effective or more effect than tcas, but can be very dangerous: second generation antidepressants, etc. (1980s, ssri"s (1990s, snri"s recent (1990s-2000+) Use antidepressants with care because it can exacerbate mania (which is the more severe) symptom: lithium carbonate (1950s) This is the mainstay, majority of people respond to it.
