PCL102H1 Lecture Notes - Phencyclidine, Cold Turkey, Inverse Agonist
Document Summary
Unsuccessful are about a third. (3+% of the population?) Epilepsy and schizophrenia are fairly rare in comparison to depression. Newer drugs ssris and snris have more tolerable side effects. Looking at the drugs we have to treat depression, newer ones are ssris and snris. Not to say they don"t have side effect but just better. The older ones are probably stronger (tricyclics and maois). So if it doesn"t work eventually they will try you on tricyclics. And dbs is experimental still but a coming therapy. All the drugs commonly used have a therapeutic delay (indirect effect). Some mainly elevate 5ht, others mainly elevate ne (maprotoline) There looks like theres at least 2 ways of relieving depression (5ht and ne) Maoai are safe and should be tried. The inhibitors of maoa, which are not quite widely used, some authors say they should be. If you use inhibitors of either maoa or maob, you will not get this cheese effect.
