PSYB32H3 Chapter Notes - Chapter 2: Excitatory Synapse, Inhibitory Postsynaptic Potential, Functional Neuroimaging
Document Summary
Chapter two current paradigms and the role of cultural. Paradigms: conceptual framework or approach within which a scientist works. The abnormality arises due to some neurological/biological issue. Product of the genotype and the phenotype: a disorder is not inherited by genetics. You can have the gene that makes you predisposed for having it. If a predisposition can be inherited, a study of the family should show a relationship with the index case (the individual with the disorder) and the probans (relatives): very true with schizophrenia. Monozygotic (mz) twins share 100% of genetic makeup. Dizygotic (dz) twins share of 50% of genetic makeup. Concordance: when twins are similar diagnostically similar: predisposition shows that the concordance between monozygotic twins should have a higher rate than dizygotic twins, this means the trait is heritable. Environment can be ruled out through this method. Look for a large collection of people in a family unit who might have a disorder.
