IMM250H1 Lecture Notes - Tlr7, Tlr9, Endosome
Document Summary
Sle patients usually photosensitive (sun exposure brings out the rash) Skin inflammation at the epidermal-dermal junction when stain for ig and complement, both are deposited at the junction, recruiting inflammatory cells tht cause skin rash. Many organs can be involved inflammation of lining of lung and heart; joint symptoms; one of their relatively more common manifestations is that can affect kidney. When look at kidney, inflammation in glomerulus, the filtering apparatus of kidney when stain the glomerulus with reagents that detect ig and complement, see deposition of ig and complement there recruit inflammatory cells, damaging kidney"s filtering apparatus. Greater than 20 times higher chance of developing lupus if in family with lupus history. Multiple genes required to act in concert to produce lupus each gene has relativelys mall effect interaction btw genes that leads to deelop to lupus phenotype. Mice models in germ-free enviornments develop lupus with same kinetics as an ordinary environment.
