IMM250H1 Lecture Notes - Interferon Gamma, Allergic Rhinitis, Agranulocyte
Document Summary
Pirquet definition still valid acquired (not innate); specific; physical substances. Think about immune system going awry either too much or too little. Allergy is most common immune disorder there is. Most common cause = hygiene hypothesis too sterile a living environment previously, immune system constantly challenged by the dirtiness. Look at populations with endemic parasites low rates of allergy suggesting that the immune system arm for allergy is designed for something else, like parasites. Birth time: born in spring, greater incidence of allergy; climate change; western industrialized world, with its chemicals so exposure to things that previously were not exposed to. Diesel particles very immunogenic great as adjuvants diesel exhaust could be contributing to increased immune responses. Fewer siblings; bottle feeding; diet; use of antibiotics (not only do they wipe out pathogenic bacteria, can wipe out commensal bacteria) flora that exist in gut in probiotic fashion that contributes to health.
