CSB202H1 Lecture Notes - Health Canada, Clinical Trial, Antigen
3 Jun 2013
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Document Summary
A clinical and public health perspective on vaccines. Vaccinology science of understanding host and pathogen, and getting the host to protect itself against future pathogens . Temporal causal association; future risk humans view vaccine with distrust, opposed to antibiotics. 1880s, london, england water sanitation john snow thought that water was causing cholera. Epideiomology infer pathogenesis of disease from studies of population that get disease; After food and water, vaccines are most important. Invasive hib disease first vaccine where it was clear that it wasn"t increasing socioeconomic status and changes in toher things, but the vaccine itself, was the one against hemophohilus influenza type b (hib) Antigen people respond to is a polyscharride antigen kids under two cannot be vaccinated, because do not respond to it. Increase in cases from 80 to 86 due to reporting artifact reporting sensitivity goes up because once the vaccine was announced, reporting became more useful.
