BMS2021 Study Guide - Oxaloacetic Acid, Homeostasis, Allostasis

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apricotbutterfly809

8 Jul 2013

School

Monash University

Department

Biomedical Sciences

Course

BMS2021

Professor

Prof.Christina Mitchell

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Document Summary

The reason this structure exists enables glucose to be stored in the body. It is primary found in 2 stores within the body. 10% of the livers weight is this glycogen. It is an important store of energy in the body. In provide a quick source of energy for the energy. This glycogen is a reservoir of energy, especially for neurons. Skeletal muscle glycogen can be used for aerobic and anaerobic glycogen, this last one hour. When glucose levels within the blood falls, glycogenolysis occurs to raise these glucose levels within the blood. Stored in the liver, glycogen is found in a-1,4 glygocidic bond. This is the breakdown of glycogen, to glucose-1- phosphate. This involves many enzymes, in particular glycogen phosphorylase, glycogen debranching enzyme and phosphoglycomutase. Glycogen phospholoase, is a homodimeric enzyme subject to allosteric control. This is known as the branched portion of glycogen.

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i need question number nine please

Case Study Section 2 â glycolysis
Based on âMonday at the Metabolic Clinic, Adventures in Glycolysisâ by Nancy Boury (National Center for Case Study Teaching in Science)

Background:
You have been chosen for a very competitive undergraduate clinical internship at St. Visintainerâs Hospital and Metabolic Clinic working with Dr. Saccharo, an expert in enzyme deficiency disorders related to glycolysis. Before your first day Dr. Saccharo has asked that you review the reactions of glycolysis and the concept of isoenzymes.

Recall that isoenzymes are groups of enzymes that catalyze the same reaction in that they use the same reactants to product the same products. They may have different genes, tissue expression, developmental timing of expression, and affinities for their substrates. As an example, phosphofructokinase-1 has 3 isoenzyme forms: PFK-L is expressed in the liver and the gene is found on chromosome 21; PFK-M is expressed in the muscle and the gene is found on chromosome 12; and PFK-P is expressed in platelets and the gene is found on chromosome 10.

Question 1:
If a person would be deficient in all 3 forms of PFK-1, this person would .
A. Have lower than normal glycogen stores.
B. Have more mitochondrial activity than normal.
C. Be dead.
D. Produce more energy per glucose molecule because glycolysis would be unregulated.

It is now Monday morning and you are ready to start seeing patients with Dr. Saccharo.

Patient 1:
Ann is a teenager and avid golfer who was referred to the clinic after being refused at the blood drive and tiring easily on the high school golf course during practice. Ann is examined and a blood sample was obtained for analysis of a glycolysis related metabolic panel. The results of her panel is below (levels: + = normal, - = decreased; ++= increased):
Blood Metabolic Panel
Blood Glucose +
Glucose-6-phosphate ++
Fructose-6-phosphate ++
Fructose-1,6,bisphosphate ++
Glyceraldehyde-3-phosphate ++
1,3-bisphosphoglycerate ++
Phosphoenolpyruvate ++
Pyruvate -
ATP -
Red Blood Cell Concentration -
Question 2:
Assuming that Dr. Saccharo is correctly assuming that Ann has a defect in glycolysis, what glycolytic enzyme is the most likely to have the defect based on the blood metabolic profile?
A. Hexokinase
B. Phosphofructokinase
C. Triose Phosphate Isomerase
D. Pyruvate Kinase
E. Aldolase

Patient 2:
Marie is a 32-year-old mother of three complaining of fatigue and muscle cramps with exercise. She had always blamed her intolerance to exercise on her sedentary lifestyle. However, she recently joined a gym and after a week of aerobics classes went to her physician, who ordered a series of blood tests. The blood work came back with abnormal results, leading to her muscle biopsy and referral to the metabolic clinic. Marieâs blood was subjected to the same metabolic panel used before with the following results:
Blood Metabolic Panel
Blood Glucose +
Glucose-6-phosphate ++
Fructose-6-phosphate ++
Fructose-1,6,bisphosphate -
Glyceraldehyde-3-phosphate -
1,3-bisphosphoglycerate -
Pyruvate -
ATP -
Red Blood Cell Concentration -

Marieâs muscle biopsy was also analyzed and showed an excess of glycogen.

Question 3:
What is the most likely enzyme deficiency for Marie?
A. Hexokinase
B. Phosphofructokinase
C. Triose Phosphate Isomerase
D. Pyruvate Kinase
E. Aldolase

Question 4:
If you wanted to test the ability of red blood cells to complete glycolysis what compound would you try to detect?
A. Fructose-6-phosphate
B. Aldolase
C. Pyruvate
D. Phosphofructokinase
E. Dihydroxyacetone phosphate

Question 5:
If you used a sample of Marieâs blood for this, what compound could you add to enable these cells to complete glycolysis?
A. Glucose
B. Fructose-1,6-bisphosphate
C. Insulin
D. Glucagon
E. Fructose-6-phosphate

Patient 3:
Leo is a 25-year-old accountant that is not anemic, has perfect teeth, but has experienced two fainting spells recently. One happened after accidentally drinking a non-diet soda; the other after eating ânaturally sweetenedâ fruit salad. His dentist referred him to Dr. Saccharoâs clinic. Dr. Saccharo suspects Leo may have Hereditary Fructose Intolerance (HFI) and has recommended a closely monitored fructose tolerance test.

Hereditary Fructose Intolerance is a recessive disorder where individuals lack a functional copy of one isoform of the enzyme aldolase, specifically Aldolase B (also known as fructose-1-phosphate aldolase). In the liver, fructose is phosphorylated by Fructokinase to fructose-1-phosphate, then is cleaved by Aldolase B to glyceraldehyde and dihydroxyacetone phosphate. Fructose-1-phosphate is also a known allosteric inhibitor of Glycogen Phosphorylase, the primary enzyme responsible for releasing glucose from glycogen.

Question 6:
As compared to a normal individual that consumes fructose, a person with HFI who ingested fructose would have (select all that apply):
A. High levels of blood fructose
B. High levels of blood fructose-1-phosphate
C. High levels of blood glucose
D. Low levels of blood fructose
E. Low levels of blood glucose

That afternoon Leo undergoes the fructose tolerance test with the following results:

Question 7:
Based on the results of the test, what was the effect of giving Leo the intravenous fructose?
A. A rise in blood glucose levels
B. A decrease in blood glucose levels
C. An increase in glycogen stores
D. A rapid drop in blood pressure

However there were complications: Soon after the test Leo orders and drinks a cup of tea, but after half the cup Leo passes out. Dr. Saccharo orders two sequential blood glucose checks. The first was 50 mg/dl and 15 minutes later Leoâs blood glucose was down to 40 mg/dl. With those results Dr. Saccharo injected something into Leoâs IV and within minutes Leo was back to normal.

Question 8:
From these results does it appear that Leo has HFI?
A. Yes
B. No
C. It is unclear from the results

Question 9:
What did Dr. Saccharo inject into Leoâs IV line?
A. Insulin
B. Glucagon
C. Glucose
D. Fructose
E. Phosphofructokinase

Dr. Saccharo puts Leo on a restricted diet and orders follow-up visits.

Question 10:
Which of the following foods/ingredients would Leo NOT be allowed to eat?
A. Artificial sweeteners
B. High starch foods, such as potatoes
C. Sweet tea made with cane sugar
D. Any dairy products

Dr. Saccharo puts Leo on a restricted diet and orders follow-up visits.

Case Study Section 2 â glycolysis
Based on âMonday at the Metabolic Clinic, Adventures in Glycolysisâ by Nancy Boury (National Center for Case Study Teaching in Science)

Question 9:
What did Dr. Saccharo inject into Leoâs IV line?
A. Insulin
B. Glucagon
C. Glucose
D. Fructose
E. Phosphofructokinase

indigolocust876

Question 2

The DSM-IV describes an "Eating Disorder Not OtherwiseSpecified" as:

self-starvation that leads to severe nutrient deficiencies

compulsive eating disorder

a variety of atypical eating behaviors used to maintain or lowerbody weight

recurrent episodes of extreme overeating followed byself-induced vomiting

Question 3

The nutrition paradox refers to:

coexistance of underweight and obesity in the same region

too mucn vitamin A in foods rich in vitamin C

poor countries that have excessive rates of obesity

obese children from nonobese parents

Question 4

Which of the following represents a nutrition transition?

decreased reliance on carbohydrates

increased consumption of sugar

increased availibility of maize over corn

lower-fat subsistence crops

Question 5

Which of the following is NOT part of the GOBI initiative?

breast-feeding

obesity control

immunization

growth monitoring

Question 6

Which of the following is a response to the drawbacks of theGreen Revolution?

WIC

high yield varities of grains

sustainable agriculture

biotechnology

Flag this Question

Question 70.5 pts

Worldwide, the major cause of undernutrition is:

unequal distribution of food

diseases (like AIDS)

poor farming practices

overpopulation

Question 8

Which agency monitors all confirmed causes of food-borneillness?

EPA

FDA

CDC

USDA

Question 9

In which of the following environments does Clostridiumbotulinum flourish?

acidic

alkaline

<40 degrees F

> 140 degrees F

Question 10

Which of the following is an example of food intoxication?

Norwalk virus

Salmonella

hepatitis A

Clostridium botulinum

Question 11

All of the following describe characteristics of the femaleathlete triad EXCEPT

menstrual dysfunction

disordered eating

hypertension

osteoporosis

Question 12

Impulsive, low self-esteem, seeks attention, extroverted, anderratic describe personality traits of:

bulemia nervosa

binge-eating disorder

obesity

anorexia nervosa

Question 13

Obsessive-compulsive, perfectionism, socially inhibited,compliant, and emotionally restrained describe personality traiatsof

binge-eating disorder

anorexia nervosa

bulimia nervosa

obesity

Question 14

The Institute of Medicine recommends a minimum of ________minutes of physical activity each day for adults.

Question 15

Regular exercise reduces the risk of type 2 diabetes by all butwhich of the following?

decreases the cellular uptake of blood glucose

delays the onset of complications of type 2 diabetes

increases control of blood glucose

enhances the action of insulin

Question 16

What is meant by the overload principle?

stretching a muscle group beyond the joint's healthy range ofmotion

improving fitness by placing extra physical demand on thebody

complete depletion of the body's glycogen

subjecting the body to inappropriately high stress

Question 17

The acronym FIT stands for:

fatigue, intensity, and training.

flexibility, increase, and training.

fitness, increase, and time.

frequency, intensity, and time.

Question 18

To achieve cardiorespiratory fitness it is recommended thattraining should occur ________.

3-5 days a week

daily

more than 5 days a week

2-3 days a week

Question 19

To achieve and maintain physical fitness, exercise intensityshould be ________ of the maximal heart rate.

35-50%

15-25%

25-30%

50-80%

Question 20

In which of the following types of exercise would CP (creatinephosphate) be an important source of energy?

biking up a mountain

sprinting in the 100-meter race

running a 10-kilometer road race

playing in a football game

Question 21

Which is NOT an advantage of aerobic metabolism over anaerobicmetabolism?

Much more energy is produced for every fuel molecule.

Aerobic metabolism acts more quickly.

Harmful metabolites do not accumulate as quickly.

A greater fuel supply is available.

Question 22

An unwanted effect of an overly vigorous warm-up is:

increased muscle temperature.

glycogen depletion.

increased body temperature.

reduced stress levels.

Question 23

Each day Bill power-walks for 45 minutes. Which fuel source(s)provide(s) energy during this activity?

amino acids

glucose

fatty acids

fatty acids and glucose

Question 24

The main disadvantage of using fat as a fuel is:

the body's limited storage capability.

its low energy density.

its slow metabolic breakdown.

the limitation of anaerobic metabolism.

Question 25

Joseph plays basketball for his high school team and he isconcerned that he is not consuming enough kilocalories to supporthis activity. Which of the following would be the best indicatorthat he is not consuming adequate kilocalories?

His hemoglobin is low.

His blood glucose levels are low.

His performance has been impaired.

He is losing weight.

Question 26

Rachel is a gymnast who trains 2 hours/day on average. Shesupports her daily activity by consuming 2,500 kilocalories perday. How many kilocalories should she be consuming fromcarbohydrate sources?

1,500-1,625 kilocalories

1,125-1,300 kilocalories

1,300-1,500 kilocalories

1,625-1,750 kilocalories

Question 27

The best time to replenish glycogen stores is:

the day after exercising.

a few hours before exercising.

the day before exercising.

right after exercising.

Question 28

In which of the following events would carbohydrate loading bethe most beneficial?

cross country skiing

baseball game

weight lifting

100-yard dash

Question 29

Osteoporosis, eating disorders, dehydration, and heat illnessare all possible consequences of:

the Zone diet.

carbohydrate loading.

inadequate dietary intake.

overtraining.

Question 30

Which of the following is the most potentially harmful?

heat syncope

heatstroke

heat cramps

heat exhaustion

Question 31

Which of the following athletes would be LEAST likely to developiron deficiency anemia?

a female marathon runner

a male basketball player who is a vegan

a female gymnast

a male distance swimmer

Question 32

Amenorrhea, sometimes seen in female athletes, is:

the onset of menstruation.

osteoporosis.

the loss of the menstrual cycle.

frequent diarrhea.

Question 33

Some athletes believe that caffeine can enhance athleticperformance because it has been shown to:

increase the transport of amino acids to exercising muscle.

increase muscle flexibility and strength.

increase the use of fatty acids as a fuel source.

regenerate ATP for energy.

Question 34

Which of the following ergogenic aids has been shown to enhanceshort-term exercise and resistance training?

chromium picolinate

creatine

carnatine

ephedrine

Question 35

Consuming processed foods as opposed to whole foods decreasesthe risk of contracting a food-borne illness.

True

False

Question 36

Regular physical activity can increase HDL-cholesterol.

True

False

Question 37

Nearly 1 in 6 American adults reports getting no physicalactivity at all.

True

False

Question 38

Lactic acid is a by-product of high-intensity exercise.

True

False

Question 39

Training can enhance the ability to store glycogen.

True

False

Question 40

The primary fuel source utilized in both anaerobic and aerobicexercise is protein (amino acids).

True

False

Question 41

Studies suggest that athletes need to consume more than 2grams/kg of protein each day to maintain muscle strength.

True

False

Question 420.5 pts

Refigerating or freezing foods will kill any bacteria present inthe food.

True

False

Question 43

Most athletes do not consume enough protein to support theiradded physical activity.

True

False

Question 44

Thirst is a very reliable indicator of dehydration.

True

False

1. Kidneys help to maintain a proper balance of _________ within the body.

Phosphorous

Chloride

Potassium

Calcium Phosphate

ions

All of the above

2. The nervous system has how many major categories?

3. Which major category of the nervous system contains both the Somatic and the Autonomic divisions?

Central Nervous System

Peripheral Nervous System

Neither of these

Both of these

4. Which organ or structure helps to control the master endocrine gland (pituitary gland)?

The pancreas

The thorax

Peyerâs patches

The hypothalamus

6. This tiny gland is located at the base of the brain and produces the hormone melanin.

Parathyroid

Pituitary

Hypothalamus

Pineal

7. These glands are situated right above the kidneys. The hormones produced by these glands help us to cope with stress.

Thyroid

Parathyroid

Hypothalamus

Adrenals

8. The hormones necessary for the production of sperm are produced in the __________.

Kidneys

Testes

Ovaries

None of the above

9. The bloodstream assists the endocrine organs and structures by:

Removing hormones from the body

Delivering hormones to target cells

Delivering hormones to secretory cells

The bloodstream does not come into contact with endocrine structures or organs
10. The pancreas _____________.

Is a master gland that controls many other glands

Produces progesterone and oestrogen

Is a salivary gland

Regulates blood sugar, aid in digestion

11. The basic function of the endocrine system is ________ in nature.

Digestive

Reproductive

Hormonal

Proximal

13. Urinary tract infections (UTIs) are experienced by many people during their lifetimes. Urinary tract infections can involve any bacterial infection of the urinary system structures; the kidneys, bladder, ureters, or urethra. They are caused by bacteria entering the body through the urethra and traveling upward into the body. Symptoms can range from mild discomfort when urinating to extreme pain and the loss of blood during urination. They occur more frequently in women than men, and are often treated by antibiotics in addition to home remedies, such as drinking more water and drinking cranberry juice.

Based on what you have learned about the cause of urinary tract infections, which of the following precautions would help to prevent reoccurring infections?

Taking pain medication when symptoms occur

Placing a hot pack on the abdomen when symptoms occur

Practicing good hygiene Exercising regularly

14. The nervous system is divided into two major divisions: the Central Nervous System and the Peripheral Nervous System. Those divisions have structures that can be classified as belonging to two different subdivisions: the Somatic and the Autonomic systems. The nervous system can be summarized as a complex system of interconnected nerves and special cells called neurons that are used to transmit information (by means of small electrical impulses). Use the information in the table below to help answer questions about the nervous system. Division Organs & Structures Functions Central Nervous System (CNS) Brain Spinal Cord Nerves This is the bodyâs assessment and communication center. It analyzes the information received from the sensory neurons and responds. Peripheral Nervous System (PNS) Sensory Neurons Ganglia (clusters of neurons) Nerves that connect to one another and to the CNS The sensory neurons react to physical stimuli such as light, sound, heat, and pressure, and transmit that information to the CNS. Subdivisions Description Examples Somatic The Somatic system is comprised of nerves that connect the brain and spinal cord to the muscles of the body and sensory receptors in the skin. Reactions to physical stimuli like heat or light. Using your hand to touch Eating food Autonomic The Autonomic system largely involuntary. This system controls the unconscious functions of the body. Breathing Blood Pressure

Feeling overwhelmed or startled by exposure to very loud noises is likely a reaction to information collected by which subdivision of the nervous system:

Somatic

Autonomic

No answer text provided.

15. The thyroid gland is perhaps the most well-known member of the pancreatic system. Many adults are screened for thyroid problems during routine physical exams. This butterfly shaped gland is found at the base of the neck and releases hormones that affect the bodyâs metabolism (the way the body uses energy). The thyroidâs two main hormones are T3 and T4, and they affect many body functions, including: â¢ Breathing â¢ Heart rate â¢ Central and peripheral nervous systems â¢ Body weight â¢ Muscle strength â¢ Menstrual cycles â¢ Body temperature â¢ Cholesterol levels Two common disorders associated with the thyroid include hyperthyroidism and hypothyroidism. Some of the symptoms associated with these disorders are listed in the table below. Hyperthyroidism (Too many hormones released) Hypothyroidism (Too few hormones released) Anxiety Irritability or moodiness Nervousness, hyperactivity Sweating or sensitivity to high temperatures Hand trembling (shaking) Hair loss Missed or light menstrual periods Trouble sleeping Tiredness and fatigue Difficulty concentrating Dry skin and hair Depression Sensitivity to cold temperature Frequent, heavy periods Joint and muscle pain A patient complains of arthritis-like pain in the joints of her hands, but tests for arthritis come back negative. The doctor then suggests a thyroid function test. The doctor is most likely concerned about:

High levels of T3 and T4 hormones in the body

Low levels of T3 and T4 hormones in the body

No answer text provided.

No answer text provided

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BMS2021 Study Guide - Oxaloacetic Acid, Homeostasis, Allostasis

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