PHGY 313 Lecture Notes - Metronidazole, Parasympathetic Nervous System, Clarithromycin
Document Summary
Mixing of food with gastric secretions to form chyme. Slow emptying of the chyme into the si at a suitable rate. Hcl damages duodenum and bile damages gastric mucosa: outline the cellular mechanisms involved in causing the disturbance in acid-base balance. The stomach secretes acid which is ultimately derived from water. It"s pumped across the lumenal membrane coupled with cl-. For every h+ pumped into the stomach, an hco3 is pumped into the plasma producing an alkaline tide. This tide is balanced by an acid tide from the pancrease and liver. Expand on the role of the stomach in the absorption of minreals and vitamins. Oxyntic cells release intrinsic factor which is vital for vitamin b12 absorption in ileum. In the patient, the upper part of the stomach was removed so many oxyntic cells were lost. Pernicious anemia (characterized by immature macrocytic rbcs) results 2 years later. The body has about 2 years worth of b12 in storage.