PHGY 313 Chapter Notes -Phenylalanine, Trypsinogen, Exocytosis

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The pancreas is located at the back of the abdominal wall, nuzzled in the c-shaped duodenum. The pancreatic duct joins the common bile duct and secretes into the 2nd stage of duodenum, controlled by the sphincter of oddi. Expand on the cell types present in the pancreas and the composition of pancreatic juice. Produces an alkaline secretion to neutralize stomach acid. In chronic pancreatitis, the pancreas is inflamed and the ducts are blocked and some acinar tissue is replaced by fibrotic tissue after the immune response. Consequences: decrease in enzyme activity (i. e, lipases, proteases, -amylase). Bicarbonate isn"t being released enough to neutralize the stomach acid. The overall gland structure is conserved: terminal acinar portion intercalated duct intralobular duct extralobular ducts (getting bigger and bigger) main collecting duct the pancreatic duct. The acinus is composed of pyramidal epithelial cells. Islet of langerhans is located against the secretory ducts. It is secondarily affected during chronic pancreatitis because of the inflammation.

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