Biology 1001A Midterm: Biology Notes for Midterm
1 Aug 2013
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Principles of evolution of hiv: variation, heritability, differential reproduction, change in genotype of population. Mutations produce virions that vary in drug resistance. In presence of a drug, resistant forms are more likely to reproduce than non-resistant ones. This leads to an ongoing change in genotype (and phenotype) of the population until entire population is resistant. Most common: south sahara dessert (60% -22. 5 million)/africa botswana. Epidemics are disease outbreaks not confined to a particular place, that s when they are called pandemics and are felt globally. Hiv classic example, every continent (associated with aids) The hiv pandemic over last 20 years (graphs) Proportion of kids under 15 who are hiv positive 90% = south. Radical life expectancy of someone born in 1993~ 43years old. # of people affected with hiv increasing little plateau. # of orphans due to aids increasing. Factors that explain why no cure or universal vaccine has been developed for hiv/aids. Hiv keeps evolving, treatments only work temporarily.
