PSYC62H3 Study Guide - Inverse Agonist, Partial Agonist, Agonist
Document Summary
Pharmacology may also apply to outside of the nervous system. Slide 3: synapse with terminal of one neuron adjacent to membrane of receiving neuron (post- synaptic neuron) projecting to another region. Will bind certain drugs or proteins based on receptor"s configuration selectively. Affinity does ligand fit receptor: endorphins fit opiate receptor, analogy of key and lock, some keys fit some locks easily (greater affinity for lock), but other times, not so easily (less affinity for drug) Drug can have high affinity, but low intrinsic activity and vice versa etc. Drugs act at receptors as ether agonists or antagonists. Antagonists bind to receptor and produce no biological change. Key fits lock, cannot activate lock, but can"t open door fits lock and opens door. Indirect agonist effect increasing concentration of naturally occurring ligand cocaine (endogenous agonist) Dopamine synapse transporter molecules take up dopamine into presynaptic cells cocaine binds to transporter molecules and dopamine accumulates in synapse: drug increases availability of dopamine.
