MEDSCI 206 Lecture Notes - Reelin, Granule Cell, Hindbrain
4 Sep 2013
School
Department
Course
Professor
Document Summary
As function increases through the development of the organism fetus plasticity/renewal of the brain cell decreases. Highly specialised and functional cells are formed with limited if not no renewal potential. The brain has a relatively fixed function its entire life. Proliferation of inner cell mass and migration to different regions. The ectoderm forms the brain and cns. How different types of tissue form via influence of secreted growth factors from neighbouring tissue. Main growth factors include bmp4 which works with chordin, noggin and fgf produced with by the nortochord. The presence of chordin and noggin inhibit bmp4 action allowing the ectoderm to neuralise in the absence of. The presence of fgf and bmp4 induces the formation of the spinal cord (posterior neuroectoderm) The crest of the neural tube becomes peripheral nervous system while the neural tube itself becomes the central nervous system while the somites become vertebrates.
