BIO 1140 Lecture Notes - Lecture 5: Hydrophile

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*solutes aren"t all able to cross membrane, therefore it must interact with a receptor on the inside of the cell ( for hydrophobic) for hydrophilic is must do this outside of the cell. Inject your signal compound directly into the cell. if its a surface receptor, then this will be without effect. b/c it has to bind to receptor. therefore having signal inside is no good. Integral membrane proteins, or tansmembrane proteins. on the outside of the cell they have to have a ligand binding domain, and on the inside they have to have some intracellular or cytosolic thing to activate proteins. Ligand-gated: signal molecule binds to it, and allows ions through.

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