BIO 1140 Lecture Notes - Microtubule, Phalloidin, Phagocytosis
5 Sep 2013
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Stacking multiple amount of these you get filamentous actin, and with this you end up with a filamentous actin. The filament has polarity. two filaments wound around eachother are a micro filament. Polarity b/c g-actin always stack the same way, +/- end (+ end grows faster) and same like tubulin actin can act like atpase and hydrolyse atp. Acting with atp present acting tends to be aded to a microfilament, whereas when gdp is present, it tends to disassemble, similar things to microtubule. Minus end tends to break down, plus end grows. Acting binding proteins regulate all aspects of microfilament formation: how quickly they grow, how stable they are (capping proteins to hold at certain length), they determine whether they are organized into networks or into bundles. 1. cytochalasin: prevents actin from being added to a microfilament, and as a result breaks them down.
