MELS223 Lecture Notes - Lecture 11: Septic Shock, Bacterial Adhesin, Neisseria
6 Sep 2013
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Extracellular pathogens: colonization of host cell surfaces or artificial surfaces, efficient delivery of exotoxins into the host cell. Adhesion: direct binding of bacterium to host cell. Single protein adhesins (listeria, enteropathogenic e. coli: indirect association with host cells (bridging) Fibronectin binding proteins (fnbps) staph aureus, strep pyrogenes. Expressed by uropathogenic e. coli (upec) which colonize the urinary tract and infect the kidney. Mediate bacterial adherence to epithelial cells of the bladder and kidney. Responsible for ~80% of urinary tract infections. Papg: adhesin that binds to a receptor on the surface of the human cell. Papc: outer membrane protein that forms a channel that other p- pilus components are transported through. Papd: chaperone that binds to p-pilus components in the periplasm; prevents these proteins from being degraded, and presents them to the papc channel. Assembly occurs in an ordered fashion, starting with the tip protein papg, and ending with papa and paph (not shown).
