PSYCH 2NF3 Study Guide - Midterm Guide: Aphonia, Filopodia, Tetrodotoxin
9 Sep 2013
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Concentrated in liver, gonads, gut and skin of puffer fish: not synthesized by puffer fish fish is a host for symbiotic bacteria that synthesizes it, puffer fish na+ channel is resistant due to single point mutation. 1 mg of ttx can kill an average adult human. Different na+ channels in humans have different levels of sensitivity cardiac and skeletal muscle na+ channels are resistant. Paralysis occurs due to blockage of neuron that"s stimulates muscle (not due to blockage of na+ channels on muscle) Paraesthesia = feeling funny/tingling/numbness occurs when sensory nerve fibers are involved. Lingual (tongue), face, distal (terminal anatomical regions of body; fingers toes) numbness. Generalized flaccid paralysis muscles that are paralyzed are flabby; no tension. Aphonia inability to produce sound in the voice. Severe respiratory failure and hypoxia (lack of oxygen) Unconsciousness may be due to lack of oxygen in the brain. Latency response time to stimulus higher latency; sensitivity has decreased.
