Biology 1002B Lecture Notes - Lecture 17: S Phase, Wild Type, Microrna
9 Sep 2013
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Chromatin that is loose and available to polymerase will be more likely transcribed. Functions as rna and shuts down most genes in that x. You inherit the predisposition to get cancer. Mutations in particular genes cause cancer, some correlations between cancer and mutation in certain genes. Some environmental agents that cause cancer seem to be mutagens. Genetic make up puts the body in an environment that makes you more likely to get cancer. Cdk(inase)- regulators (enzymes) of protein expression by phosphorylation are constitutive. However inactive unless bound to respective cyclin protein. Both combine and phosphorylate a whole range of proteins down stream to drive cell cycle. Cdk2 and cyclin e combine to drive cell thru g0 checkpoin. Under the influence of external and internal controls, cell may actively cycle, sit in g0 or undergo apoptosis. Expression of proto-oncogenes promotes cell cycling: eg egfr (epidermal growth factor) Also expressed during embryonic growth (are same as those that are expressed in tumour)
