Biology 1002B Lecture Notes - Lecture 19: Transversion, Rodent, Ames Test

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Primase doesn"t need a 3" oh that"s properly paired to add bases to. Rna polymerases generally don"t require a properly paired 3" oh to start, dna polymerases. No 3" oh available to replace the primer. It adds telomeres to the ends of your chromosomes. Telomeres are just a repeated segment of dna over and over again. Telomerase has its own template (own bit of rna that is uses as a template) Making dna from an rna template is unusual. Once we increase the 3" end, we can replicate backwards. Cells with short teomoeres have replicated a number of times. Can detect how od cells are from this length. Telomerase is mostly off in most cells most of the time: during gametogenesis, telomeres are added. Telomerase also doesn"t" prevent cell from getting shorter, it just acts against it by making dna longer so that it doesn"t matter if they shorten (the garbage added to the end doesn"t matter if it shortens)

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