BISC 220Lg Lecture : Lecture_9-10.pdf
Document Summary
1 ligand to 8 response molecules amplifies signal (by 8 folds) Adenylyl cyclase converts atp to camp in response to extracellular signal epinephrine. Epinephrine is need to boost cytosolic concentrations of camp again. Why is camp impt? turns on protein kinase a (phosphorylates other proteins catalyzes transfer of phosphate groups) 1 cascade is going merrily another interrupts and prevents it from going base a certain point another might be able to further the cascade (make it faster) Proteins persist in active form long enough to process numerous molecules of substrate before becoming inactive substrates, which are also proteins can continue, creating more and more insert more glucose transporters to increase conc of glucose. 2 cells respond diff to same signal differ in 1+ proteins that handle & respond to signal. Cell c: branching of pathways & cross-talk (interaction) b/w pathways are impt in regulating & coordinating cell"s response to info coming from diff sources in body.
