MICRB265 Lecture Notes - Glycoconjugate, Oligosaccharide, Mycobacterium
13 Sep 2013
School
Department
Course
Professor
Document Summary
Micrb 265 guest lecture (september 11, 2013) In gram-positive cells, the peptidoglycan is outside of the cell. If you get rid of it, the bacterium will die. Glycoconjugate synthesis: sugars activated, subunits are assembles in the cytoplasm, transfer subunit onto lipid, flipping across membrane into periplasm, sugars put together, then exported outside of cell membrane. Difficult though as peptidoglycan is a large molecule and therefore difficult to get through. Mycobacteria is a crazy" bacteria: produces a lot of weird polysaccharides, sugars made that we have never seen in other organisms. Humans have l amino acids : similar to d amino acids. General purpose of antibiotics: kill the bacteria while being non-toxic to the host. Bacteria need enzymes in order to divide. Lipopolysaccharides are referred to as the basics : lipid a connected to an inner core oligosaccharide, then an outer core oligosaccharide, and finally repeat o-antigen unit(s) O-antigens and capsules are implemented by bacteria to protect from human immune system.
