BIOL 2021 Lecture Notes - Protein Kinase A, Adenylyl Cyclase, Cyclic Adenosine Monophosphate
Document Summary
Of all drugs are targeted to these receptors/pathways. Always a multipass transmembrane protein with a 7 membrane span (passes through the. Take signals from the outside and transfer them. 700 gpcr in human genome plasma membrane 7 times) Gpcr work through trimeric g-protein (3 subunits) Beta and gamma subunits form a complex. Alpha and gamma subunits are membrane bound and have fatty acids integral in plasma membrane. There are many g proteins that are specific for gpcr and target. In trimeric proteins, gef activated the exchange of gdp for gtp on gpcr (activating pathway) Active receptor cause a conformational change of g protein to give an active g protein. Many g proteins are activated by active receptors. Amplification-> small signal amplified to cause a big signal. Targets can be on ion channels or enzymes. Signal is ended by alpha gtpase which hydrolyses gtp-> gdp, making it inactive. To inactivate receptor, receptor gets phosphorylated (receptor kinase)
