BIOL 2021 Lecture Notes - Intermediate Filament, Globular Protein, Cytoskeleton

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16 Oct 2011
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Gives cell strength, shape, movement of cells. Gene sequences are conserved (gene sequences are similar in all species) Rigid, forms trackways which vesicles move along. Only in some metazoans (not in all eukaryotes); only in some cell types (specialized functions) Assembled with non covalent interactions so rapid changes can occur in cytoskeleton. Span across a cell and gives it strength and toughness. Line protofilaments together to make helical filaments (like a cable) Disable and reassemble filaments to change directions. In nucleation you first need a few subunits to attach to something (like in recrystallization) Globular, two kinds of tubulin: and . Beta- gtp will hydrolyse and exchange (where energy is generated) Always have alpha at one end called the - end. Beta is at the other end, called the + end. Protofilmanet= actin subunits lined up head to head in a row. Polarity -> + and end (actin is not symmetric)

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