PSYC 3030 : Neurotransmitters.docx

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Document Summary

Vmat2, amphetamine and methamphetami ne stimulate release of da, cocaine inhibits. Beta-blockers are used to treat anxiety disorders, amphetamine and methamphetami ne stimulate release of ne, Reserpine blocks action of vmat2, amphetamine and methamphetami ne can stimulate release of 5-ht, D1-like receptors (d1, d5) - metabotropic, stimulate adenylate cyclase (vta ventral striatum [nucleus. Metabotropic, inhibit accumbens], involved adenylate cyclase and open k+ in reward) channels (autoreceptor) 1 receptors - metabotropic, stimulate phospholipase c pathway. 1 and 2 receptors - metabotropic, stimulate adenylate cyclase. 5-ht1a - metabotropic, inhibit adenylate cyclase and open k+ channels, 5-ht1 (5) 5-ht2a - metabotropic, stimulates phospholipase c pathway, 5-ht2 (3) Nicotinic receptors - ionotropic, heteromeric ([ 4]2[ 2]3) or homomeric ([ 7]5), allows na+ and ca2+ to enter the cell. M5) - metabotropic, m5 operates via second messengers and opens k+ channels. Ampa receptors - ionotropic, allows na+ into the cell. Kainate receptors - ionotropic, allows na+ into the cell.