BIO230H1 Lecture Notes - Lecture 4: Histone Acetyltransferase, Dna-Binding Domain, Histone H3
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BIO230H1 Full Course Notes
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Transcription is conducted by rna polymerase that transcribes dna into rna. There are different types of rnas that can be produced by rna polymerase; we will be talking about mrna because it is the one that produces proteins. Rna polymerase and prokaryotes only have one; we talk about rna polymerase ii because it transcribes mrna. In eukaryotes, the initiation of transcription requires 5 general transcription factors. Recall that in prokaryotes, the rna polymerase only needed sigma factor. These general transcription factors are required for all promoters that are used by rna polymerase ii. Tfiid recognizes the tata box; this then recruits tfiib, which then tells rna polymerase ii where to start. Tfiih is recruited along with rna polymerase ii and it is involved in unwinding the dna and in phosphorylating the c-terminal tail of rna polymerase; this phosphorylation kick-starts transcription. Once all of these transcription factors get onto the promoter, then transcription can start.
