BIO230H1 Lecture Notes - Lecture 2: Lac Operon, Lac Repressor, Sigma Factor
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BIO230H1 Full Course Notes
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Recall that the central dogma dictates that the genome is transcribed into the transcriptome that is then translated into the proteome. The players in these steps are dna for the genome that is transcribed by rna polymerase into rna which is then translated by ribosomes into proteins. Transcriptional regulation is crucial for a number of reasons: Cells also need to know how to response to extracellular cues like hormones appropriately. These responses usually involve transcriptional responses and alterations in the rna levels. It is also important for defining cell types. In a multicellular organism, each cell type in different tissues has different functions and is structurally different. Differences in their transcriptome is what causes these different functions to arise; they express different parts of the same genome in order to carry out their different functions. It also defines different cell types in terms of disease states.
