CSB327H1 Lecture Notes - Lecture 2: Flat Bone, Sclera, Glycosylation

• School: UTSG
• Department: Cell and Systems Biology
• Course: CSB327H1
• Professor: Maurice Ringuette

Document Summary

Lecture 2 collagen classification, nomenclature and supramolecular organization of type 1. We can classify collagens based on their supramolecular organization. Fibril forming = signature = t1c: can see collagen molecules are lined up in a staggered way, can begin to see dark like bands due to repeated staggering. Network forming e. g. type 4 collagen signature collagen of basal lamina. Always a triple helix bc it is collagenous. Signature molecular composition a1(i)2a2(i), considered a heterotrimer: genes: col1a1 and col1a2 for a1 and a2 chains respectively. Homotrimers = three of the same a-chains i. e. only requiring one transcriptional unit. A1(1)a2(ii) = does not exist in nature - diff combinations of alpha chains can exist but number in brackets must be same. A1(iv)a2(iv)a3(iv)2 = no, bc four alpha chains cannot exist in a collagenous form. A3(iv)a4(iv)a5(iv) = yes, t4c has 6 genes. Genes col(collagen #)a(alpha chain #) e. g. col1a2 codes for alpha 2 chain of collagen type 1.