BIOL207 Lecture Notes - Lecture 16: Gamete, Achondroplasia, Sperm Bank
21 Oct 2013
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Lecture 16: human pedigree analysis part 2 (con"t) | lecture 17: Population genetics | lecture 18: interactions between genes part 1. Pedigree charts not good for new mutation: example: achondroplasia is usually a brand new mutation (less likely to be inherited than to occur due to spontaneous mutation) The older the dad is, the more likely the child is likely to develop. Most sperm will end up carrying the mutation. New mutations: pedigree charts are best used for inherited mutations. Adoption: testing errors, people don"t admit to having serious conditions (societal stigma) Multifactorial diseases: most disease are not a result of a single mutated allele but rather, mutant alleles of several genes and the effect of the environment. Frequencies of genotypes and phenotypes in a genetic cross. 2 x (freq. first allele) * (freq. Q = frequency of second allele: genotypes total 1: P2 + 2pq + q2 = 1: example: pku in canada.
