PHAR 300 Lecture Notes - Lecture 6: Nicotine Replacement Therapy, Chemoreceptor Trigger Zone, Drug Delivery

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Question: tolerance to a centrally active drug ( acting on cns) can result from: Lecture 6- nicotine: decrease in r number, increase in r number, decrease in transmitter synthesis, increase in transmitter synthesis, all of the above. Answer: 5 cns has all sorts of techniques it can use to counteract the effect of drugs (adaptation, tolerance) The nicotinic receptor is called nicotinic because it is nicotine that stimulates it. Nicotine is a natural ingredient of the tobacco plant. It is the active drug that people get addicted to in cigarettes. It takes about 7 seconds for the nicotine to get from the lungs to the brain. Deaths from cigarette is very large ( as seen in the pie chart) 6 million people per year die from cigarette. 30% of cancer deaths are due to smoking: breast, prostate, bladder, etc . lung. There is a correlation between the inability to clear substances out of your lungs and the amount you smoke.