BIOL 205 Lecture : Lecture22-23.pdf

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Biol 205: week 8, lectures 22 and 23 (combined) An oncogene-induced dna damage model for cancer development. Thanos d. halazonetis, vassilis g. gorgoulis, jiri bartek. Of all types of dna damage, dna double-strand breaks (dsbs) pose the greatest challenge to cells. One might have, therefore, anticipated that a sizable number of dna dsbs would be incompatible with cell proliferation. Yet recent experimental findings suggest that, in both precancerous lesions and cancers, activated oncogenes induce stalling and collapse of dna replication forks, which in turn leads to formation of dna dsbs. Dsbs may contribute to the genomic instability that characterizes the vast majority of human cancers. In addition, in precancerous lesions, these dna dsbs activate p53, which, by inducing apoptosis or senescence, raises a barrier to tumor progression. Breach of this barrier by various mechanisms, most notably by p53 mutations, that impair the dna damage response pathway allows cancers to develop.

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